|
KMID : 0620920160480060002
|
|
Experimental & Molecular Medicine
2016 Volume.48 No. 6 p.2 ~ p.2
|
|
|
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
|
|
Ha Jung-Min
Baek Seung-Hoon
Kim Young-Hwan
Jin Seo-Yeon
Lee Hye-Sun
Kim Sun-Ja
Shin Hwa-Kyoung
Lee Dong-Hyung
Song Sang-Heon
Kim Chi-Dae
Bae Sun-Sik
|
|
|
Abstract
|
|
|
|
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|